山西医科大学学报2012，Vol.43Issue(9)：679-683,5.DOI:10.3969/J.ISSN.1007-6611.2012.09.012
轻度认知功能损害及阿尔茨海默病氢质子磁共振波谱研究
Magnetic resonance spectroscopy for mild cognitive impairment and Alzheimer' s disease
王斐 1鱼博浪 1金晨望 1王渊1
作者信息
- 1. 西安交通大学医学院第一附属医院影像中心,西安710061
- 折叠
摘要
Abstract
Objective To evaluate the role of ' H-MRS changes in the hippocampus and the posterior cingulated gyms in the diagnosis of mild cognitive impairment( MCI) and early Alzheimer' s disease( AD) . Methods H-MRS was performed to examine the levels of N-acetyl aspartic acid(NAA) ,choline(Cho) ,creatine( Cr) ,myoinositol( ml) in the frontal lobe,the posterior cingulated gyrus and the hippocampus in 30 cases of AD, 30 cases of MCI, and 30 cases of age-matched healthy controls. Results Compared with normal group, NAA/ml was significantly decreased and ml/Cr was significantly enhanced in hippocampus and posterior cingulated gyrus in AD and MCI groups( P < 0.05). In frontal lobe,NAA/ml was significantly decreased compared with normal group. In these three brain areas, NAA/ml in AD group was significantly lower than in MCI group(P <0.05). With the disease developing from the normal,MCI to AD,mI/Cr gradually increased and NAA/ml gradually decreased(P <0.05). The difference of NAA/ml between AD patients and controls was significantly larger in the hippocampus than those in the posterior cingulated gyrus and the frontal lobe,while the difference of NAA/ml between MCI patients and controls was significantly smaller in the hippocampus than those in the posterior cingulated gyrus and the frontal lobe. Conclusion MRS is a very good method in the diagnosis of MCI and AD. NAA/ml ratio in different brain regions is an important index for detecting AD and MCI.关键词
轻度认知功能损害/阿尔茨海默病/磁共振波谱Key words
mild cognitive impairment/Alzheimer' s disease/magnetic resonance spectroscopy分类
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王斐,鱼博浪,金晨望,王渊..轻度认知功能损害及阿尔茨海默病氢质子磁共振波谱研究[J].山西医科大学学报,2012,43(9):679-683,5.
