摘要
Abstract
Objective To explore the effect of tramadol and propofol on cardiovascular changes during tracheal extubation in aged patients. Methods Forty patients undergoing abdominal operation were randomly and equally divided into observation group and control group. Before tracheal extubation,patients were given intravenously tramadol 1.0 mg/kg and propofol 0.5 mg/kg in observation group, and 10 ml physiological saline in control group. Heart rate(HR) , systolic blood pressure (SBP) .diastolic blood pressure(DBP) ,mean arterial pressure (MAP),oxygen saturation(SpO2) ,and the incidence of nausea, vomiting,agitation were recorded 5 min before extubation, at the tracheal extubation and 5 min after tracheal extubation. Concentrations of norepinephrine ( NE) and epinephrine ( E ) were analyzed at the tracheal extubation and 10 min after extubation. Results At the tracheal extubation, HR, SBP, DBP, MAP increased significantly in control group,while HR,SBP,DBP,MAP kept more stable in observation group than those in control group(P<0. 05). Plasma E was significantly higher in control group 10 min after extubation than that before extubation(P <0.05) ,but NE level had no significant change. Plasma E and NE showed no significant changes in observation group. Plasma E was significantly lower in observation group than in control group 10 min after extubation ( P < 0. 05 ). The incidence of nausea and vomiting in observation group was lower than in control group, but there was no statistical difference between two groups ( P > 0.05 ). Conclusion The small doses of tramadol and propofol in the aged patients can effectively prevent the tracheal extubation-induced cardiovascular responses with few adverse reactions.关键词
丙泊酚/曲马多/拔管/老年人Key words
tramadol/propofol/tracheal extubation/aged分类
医药卫生
