摘要
Abstract
Objective To explore the relationship of children who had allergic purpura and immune function,also,provide the experimental basis for clinicalt hrough the analysis of allergic purpura in children with T-cell subsets,serum immunoglobu-lin's,and the change of serum complement. Methods Henoch-Schonlein (allergic) purpura in children hospitalized in the First Affiliated Hospital of Xi'an Jiaotong University Medicine School from January to October in 2011, the diagnosis of allergic purpura were under the standards of allergic purpura diagnostic criteria which developed by the American Rheumatism Association (ARA) in 1990. There were total 45 cases,26 males and 19 females, from 2 to 14 years old;the average age was 8. 1 years. Control group:healthy children, there were total 20 cases, 10 males and 10 females,from 3 to 13 years old; the average age was 7. 6 years. Compared the age and sex of allergic purpura group and the control group, the difference was not statistically significant. Used polychromatic flow cytometry to measure T cell subsets, and used turbidimetry immunohisto-chemical scattering to measure serum immunoglobulins and serum complement. Results There was obvious change in Henoch-Schonlein purpura in children with T cell subsets,CD3 + CD4 + (Th) was significantly lower than those of the control group, t=2. 91,P<0 01;of CD3 + CD4+(Th)/CD3 + CD8 +(Ts)ratio was decreased,compared to the control group, t= 2. 80, P<0.01. The IgA levels of allergic purpura serum were significantly higher than those in the control group, 1=2. 76, P<0 01. Compared the serum complement indicators between the allergic children and the control group, there were no difference. Conclusion Henoch-Schonlein (allergic) purpura children have abnormal cellular and humoral immune function. So to detect the immune function of children with allergic purpura can help determine the condition and guide treatment.关键词
过敏性紫癜/T细胞亚群/免疫球蛋白/血清补体Key words
henoch-schonlein (allergic) purpura/T cell subsets/immunoglobulin/serum complement分类
医药卫生
