现代检验医学杂志2012，Vol.27Issue(4)：139-141,3.DOI:10.3969/j.issn.1671-7414.2012.04.054
HBsAg阳性孕妇血清HBV-DNA含量与胎儿宫内感染关系探讨
Correlative Study on Serum Hepatitis B Virus DNA Level of Gravidas with Mother-to-Infant Transmission
唐芳玫 1宁日平 1李颖1
作者信息
- 1. 广西中医学院附属瑞康医院检验科,南宁 530011
- 折叠
摘要
Abstract
Objective To investigate the relationship between serum hepatitis B virus DNA (HBV-DNA) level of gravida and mother-to-infant transmission. Methods HBV-DNA were quantitatively examined by FQ-PCR in 92 pregnant women detected positive for HBV and their newborns,and serologic HBV markers were detected by enzyme linked immunoadsorbent assay (ELISA). Results HBV-DNA positive rate of infant umbilical cord blood was 18.5% (17/92) .which was significantly higher than HBsAg positive rate 5.4% (5/92) (P<0. 01). HBV-DNA positive rate of newborns born to HBeAg ( + ) motherwas 41.2% (14/34), which was significantly higher than those born to HBeAg( —) mother 5. 2% (3/58) ( P< 0.01) ; HBV-DNA and intrauterine fetal infection rates were positively correlated. Conclusion Using FQ-PCR to detect HBV-DNA of umbilical cord blood in newborn infants is a sensitive screenmethod inmonitoring intrauterine HBV transmission. High level of HBV-DNA in pregnantwomen is one of the high risk factors of intrauterine HBV transmission and infection.关键词
乙型肝炎病毒/HBV-DNA/聚合酶连反应/宫内感染Key words
hepatitis B virus/ HBV-DNA /polymerase chain reaction/intrauterine infection分类
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唐芳玫,宁日平,李颖..HBsAg阳性孕妇血清HBV-DNA含量与胎儿宫内感染关系探讨[J].现代检验医学杂志,2012,27(4):139-141,3.
