Abstract
Objective To intervention,observe dynamicly hemorrhagic stroke patients interieukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) content change with dexamethasone and to discuss the hemorrhage secondary brain injury in the role. Methods Used ELISA method to determined serum IL-6 ,TNF-a content level of 50 cases with hemorrhagic stroke patients through conventional treatment and 50 cases with dexamethasone routine therapy treatment,after postoperative day l,day 3, day 7,day 10 serum. Compared the quality of life in twe groups. Results Two groups of patients postoperative day 1 routine therapy group IL-6:134. 73 ±29. 64μg/L,TNF-α:57. 62 ±5. 13 μg/L; Dexamethasone therapy group IL-6:36. 65 ±31. 56 μg/L,TNF-α:56. 84 ±5. 03 μg/L,compared to both no significant difference (t=l. 06,1. 14, P>0. 05) ,and normal control group (IL-6: 27. 84±7. 76 μg/L; TNF-α: 40. 27 ± 4. 85 μg/L) compared with significant difference (t = 5. 29 , 4. 41, P< 0. 001), the third day after the routine treatment group IL-6:120. 51 + 30. 75 μg/L,TNF-α: 59. 24±4. 72 μg/ L; Dexamethasone therapy group IL-6 : 108. 47 ± 26. 73 fxg/L, TNF-a: 46. 75 ± 4. 64 μg/L, compared to two significant difference ( t = 2. 42,2. 35,P<0. 05), the seventh day of the routine treatment group IL-6: 70. 65 ±17. 73 μg/L,TNF-α:50. 62 ±5. 11 μg/ L;Dexamethasone therapy group IL-6:58. 16±14. 65 μg/L,TNF-α:41. 64±5. 01 μg/L,compared to two significant difference (t=2. 81,2. 76, P< 0. 05), day 10 routine therapy group IL-6:34. 52 ±8. 92 μg/L,TNF-α:46. 27 ±4. 43 μg/L;Dexam-ethasone therapy group IL-6 : 28. 17 ± 7. 45 μg/L, TNF-α: 40. 89 ± 4. 27 μg/L, compared to two significant difference (t= 2. 34,2. 56,P< 0.05). Two groups of patients in hospital admission neural function defect score ( NDS routine therapy group 37. 12±4. 56, dexamethasone therapy group 38. 05±4. 72) and daily life quality score (ADD routine therapy group 67. 35 + 8. 95,69, 02±7. 74 dex treatment group,had no significant difference (t=0. 98 ,0. 79 , P>0. 05) , the hospital two groups of patients NDS (conventional treatment group 26. 13 + 3. 89,dexamethasone therapy group 16. 74±3. 26) and ADL (conventional treatment group 45. 43± 6. 77 , dexamethasone therapy group 38. 64 ± 5. 49) significant difference (t= 3. 54,2. 96,P<0. 01). Conclusion IL-6,TNF- α mediated a hemorrhagic stroke patients of inflammatory reaction,effective control of its content,to reduce hemorrhagic stroke secondary brain injury and improve after survival ability has the positive significance.关键词
出血性脑卒中/白细胞介素-6(IL-6)/肿瘤坏死因子(TNF-α)/地塞米松Key words
hemorrhagic stroke/interleukin 6(IL-6) /tumor necrosis factor (TNF-α) /dexamethasone分类
医药卫生
