现代检验医学杂志2012，Vol.27Issue(5)：80-82,3.DOI:10.3969/j.issn.1671-7414.2012.05.027
汉中地区Rh阴性个体D基因多态性的研究
Study on RHD Polymorphism in Rh Negative Individuals in Hanzhong
摘要
Abstract
Objective To study the RHD polymorphism in Rh negative individuals in Hanzhong. Methods All of the Rh-neg-ative individuals were carried out with RHD gene typing and the RHD polymorphism was analyzed. Results 248 cases of 351 real Rh-negative were d/d genotype which was about 70. 7%. 67 cases were DEL genotype which was about 19. 1%. 22 cases were RHD-CE(2-9)-D/d genotype which was about 6. 3% and 7 cases were DⅥ Ⅲ genotype which was about 2. 0%. The result was higher than the rest of the country. Among of the sample, weak D-15 type, weak D 25 type and Dva type was only one case. Weak D 33 type and RHD 711delC type was twocases. DEL blood group of individuals had a higher proportion of C antigen by,but also had the C antigen-negative phenotype. Weak D25 and weak D33 type found and reported for the first time in China. Conclusion The mainly RHD positive genotype is the DEL type. Study on of D gene polymorphism by unpaid blood donors of Rh-negative in Hanzhong reveals the Rh negative individuals D gene polymorphism. It has significance in both clinical and genetic studies.关键词
RHD基因/多态性/弱D25/弱D33型Key words
RHD gene/polymorphism/ weak D25 type/ weak D 33 type分类
医药卫生引用本文复制引用
丁珂,徐强..汉中地区Rh阴性个体D基因多态性的研究[J].现代检验医学杂志,2012,27(5):80-82,3.基金项目
陕西省科学技术研究发展计划项目(2010K16-01-12). （2010K16-01-12）
