陕西医学杂志2012，Vol.41Issue(11)：1445-1447,3.
水杨酸钠对高游离脂肪酸大鼠胰腺组织氧化应激水平的影响
Salicylate prevents pancreas tissue oxidative stress activation caused by long-term elevation of free fatty acids in vivo
摘要
Abstract
Objcctivc:To investigate the effects of sodium salicylate on FFAs-induccd rats and on oxidative stress in pancreas tissues. Methods: Intraiipid (IH), Sodium Salicylate + Intraiipid (SI), and saline (SAL) were intravenously infused for 48h in rats. The maiondiaidchydc (MDA) content, Supcroxidc Dismutasc (SOD) activity and the expression of duodenal homcobox-1 (PDX-1) mRNA in pancreas were examined. Results: Compared with SAL group, there was elevated 1. 6 times of MDA/SOD in pancreas tissues in rats with IH, the ratio decreased 30% in SI group. Infusion of IH markedly decreased the express of PDX-lmRNA, which were obviously prevented by salicylate co-infusion. Conclusion: This study provides preliminary assessments of efficacy of sodium salicylate as a new treatment for FFAs-induccd β cell dysfunction. The effect of decreasing β cell apoptosis by salicylate in part may be secondary to reduce the oxidative stress in pancreas.关键词
胰腺/药物作用/水杨酸钠/治疗应用/氧化应激/游离脂肪酸/大鼠Key words
Pancreas/drug effects Sodium salicylatc/thcrapcutic use @Oxidative stress @Free fatty acids/ Rats分类
医药卫生引用本文复制引用
何冰,马晓丹,张微,韩萍..水杨酸钠对高游离脂肪酸大鼠胰腺组织氧化应激水平的影响[J].陕西医学杂志,2012,41(11):1445-1447,3.基金项目
辽宁省教育厅资助(编号:20060999) （编号:20060999）
