实用妇产科杂志2012，Vol.28Issue(7)：541-545,5.
年轻妇女子宫内膜癌626例临床分析
Clinical Analysis of 626 Young Patients with Endometrial Carcinoma
摘要
Abstract
Objectives: To assess the characteristics of young women with endometrial carcinoma. Methods: We retrospectively analyzed young women ( ≤40 years) diagnosed with endometrial cancer from 34 hospitals between 2000 and 2010 in Guangdong province. Results: The percentage of young patients was not tended to be ascending from 2000 to 2010, and theirs mean age at diagnosis was not tended to be descending. Endometrioid adenocarcinoma was found in 93.6% young patients. 92.0% young patients were G1 and G2 , 87.2% young patients were. ss1/2 myometrial invasion . The overall distributions by stages were stage Ⅰ 71.6%, Ⅱ 10.6%, Ⅲ 16.1%, and Ⅳ 1.7%. The percentage of preoperative misdiagnose was 19.0%, and the error rates of pre-operative clinical stage Ⅰ,Ⅱ,Ⅲ were 18.6%, 53.5%, 18.9%, respectively. Ovarian metastasis was correlated with histological grades G3 ( P＜0.01), deep myometrial invasion (P＜ 0.01 ), positive abdominal dropsy cytology ( P ＜0. 01). But multivariate analysis did not show statistic significance. Lymph node metastasis was correlated with histological grades G3( P＜0.01), deep myometrial invasion (P ＜ 0. 01 ), cervical invasion ( P ＜ 0. 01), positive abdominal dropsy cytology ( P ＜ 0.05). lymphatic vascular invasion (P ＜ 0.01). But the multivariate analysis showed that only histological grades G3(P＜0.05)and cervical invasion( P＜0.05)were statistically significant . Conclusions: A certain proportion of endometrial cancer are young patients, but there isn' t a trend of more young patients. The pathological characteristics in young patients with endometrial cancer tend to be diagnosed at an early stage, G1/G2 endometrioid adenocarcinoma. Preoperative misdiagnosis is really common in clinic. Cervical invasion and G3 are independent risk factors for lymph node metastasis.关键词
子宫内膜癌/发病趋势/误诊/病理/高危因素Key words
Endometrial cancer/ Incidence trend/ Misdiagnose/ Pathology/ High risk factors分类
医药卫生引用本文复制引用
李小毛,刘继红,何勉,陈建国,王刚..年轻妇女子宫内膜癌626例临床分析[J].实用妇产科杂志,2012,28(7):541-545,5.基金项目
广东省妇幼安康工程——子宫内膜癌防治项目(2010) （2010）
国家自然科学基金项目(编号:30772332) （编号:30772332）
广东省科技计划项目(编号:2010B031600035) （编号:2010B031600035）
