实用妇产科杂志2012，Vol.28Issue(7)：576-579,4.
血清抑制素A和激活素A浓度与稽留流产的关系研究
Relationship of Ihbibin A, Activin A and Retained Abortion
摘要
Abstract
Objective: To determine the expresses of inhibin A and activin A in maternal serum of the normal early pregnancy and missed abortion, and the value of serum inhibin A in prediction of pregnancy outcome. Methods: 1000 cases of outpatient prenatal care of pregnancy 6 to 10 weeks were recruited in our hospital , serum inhibin A and activin A levels were measured by ELISA from 6 to 8 weeks and from 8 to 10 weeks respectively, and followed up until 13 weeks of gestation. Pregnancy situations, serum levels of inhibin A and activin A in normal and abortion groups , diagnostic thresould, sensitivity and specificity were compared. Results: Serum inhibin A, activin A in normal pregnancy were significantly higher than those of abortion group both in 6 to 8 gestation weeks or 8 to 10 gestation weeks,the difference was statistically significant (P＜0.01). The thresould value of serum inhibin A in predicting the abortion was ＜230 ng/L, its sensitivity was 84.8%, specificity was 77.4%; The thresould value of serum activin A in predicting the abortion was ＜ 162 ng/L, its sensitivity was 85.0%, specificity was 88.7%. There was no difference in sensitivity and specificity for these two factors (P＞0.05). Conclusions; It is feasible for serum inhibin A, activin A as a predictor of first trimester missed abortion for their high sensitivity and specificity, and there is no priority for either parameter to perform the diagnostic value.关键词
抑制素A/激活素A/稽留流产/妊娠结局Key words
Inhibin' A/ Activin A/ Missed abortion/ Pregnancy outcome分类
医药卫生引用本文复制引用
林春丽,廖湘玲..血清抑制素A和激活素A浓度与稽留流产的关系研究[J].实用妇产科杂志,2012,28(7):576-579,4.基金项目
湖南省科技厅规划项目(编号:2009FJ3185) （编号:2009FJ3185）
