实用医学杂志2012，Vol.28Issue(12)：1958-1960,3.DOI:10.3969/j.issn.1006-5725.2012.12.011
辛伐他汀对大鼠心肌梗死后交感神经重构和室性心律失常的影响
Effects of simvastatin on sympathetic remodeling and ventricular arrhythmias in rats with myocardial infarction
摘要
Abstract
Objective To investigate the effects of simvastatin on cardiac sympathetic remodeling and ventricular arrhythmias ( VA) in rats with myocardial infarction ( MI). Methods 48 SD rats were randomized to 3 groups; sham operation group (Group A), MI group (Group B), and simvastatin group (Group C). Immunohistochemistry was used to detect the distribution and density of growth associated protein-43 and tyrosine hydroxylase positive nerve in infarction border zone. Expressions of nerve growth factor, interleukin-ip, and tumor necrosis factor-a were detected by RT-PCR. Results As compared with those in Group A and C, the densities of positive nerve, targeted factors, and the incidence of VA were significantly higher in Group B (P ＜ 0.05). Conclusion Simvastatin can prevent VA through improving sympathetic remodeling in rats with MI, the mechanism may be related to reducing inflammation and the expression of NGF. A关键词
心肌梗死/辛伐他汀/室性心律失常/交感神经重构Key words
Myocardial infarction/ Simvastatin/ Ventricular arrhythmias/ Sympathetic nerve remodeling引用本文复制引用
余涛,李京波,朱伟,李帅,王法斌,魏盟..辛伐他汀对大鼠心肌梗死后交感神经重构和室性心律失常的影响[J].实用医学杂志,2012,28(12):1958-1960,3.基金项目
本课题获上海市科委基金资助(编号:11ZR1427200) （编号:11ZR1427200）
