生殖医学杂志2012，Vol.21Issue(5)：503-506,4.DOI:10.3969/j.issn.1004-3845.2012.05.024
FAS/FASL系统介导的生精细胞凋亡在男性生殖中的作用
FAS/FAS ligand-mediated apoptosis of spermatogenic cell in male reproductive system
金琪 1彭弋峰1
作者信息
- 1. 皖南医学院弋矶山医院生殖医学研究所,安徽芜湖 241001
- 折叠
摘要
Abstract
Spermatogenic cell apoptosis is a normal physiological mechanism for removing excess and defective spermatogenic cells. Excessive apoptosis could lead to oligoasthenozoospermia in the pathological state. FAS/FASL system is a main pathway mediating apoptosis of spermatogenic cells in mammalian. FAS ligand specifically combines with FAS on cell membrane, then activates caspase enzyme cascade reaction through Fas associated death domain and induces apoptosis. FAS/FASL system plays a key role in regulating apoptosis of spermatogenic cells. The combination of FAS and FAS ligand can trigger apoptosis, which is a normal physiological phenomenon during human body growth, however, over expression of this signaling pathway may adversely affect sperm quantity and quality. This paper reviewed the effect of FAS / FASL system on the apoptosis of spermatogenic cells, and discussed the male infertility caused by idiopathic oligoasthenozoospermia.关键词
FAS/FASL/生精细胞/凋亡/男性不育Key words
FAS/FASL/ Spermatogenic cell/ Apoptosis/ Male infertility引用本文复制引用
金琪,彭弋峰..FAS/FASL系统介导的生精细胞凋亡在男性生殖中的作用[J].生殖医学杂志,2012,21(5):503-506,4.
