天然产物研究与开发2012，Vol.24Issue(9)：1191-1195,5.
葡萄籽原花青素提取物对糖尿病小鼠血糖的影响
Effect of Grape Seed Proanthocyanidin Extracts on Blood Glucose of Diabetic Mice
摘要
Abstract
To investigate hypoglycemic effect and mechanism of grape seed proanthocyanidin extracts (GSPE) on diabetic mice,the diabetic model were induced by peritoneal injection of alloxan. Then the diabetic mice were divided into model control group,glibenclamide treated group,three GSPE treated groups of different dose (50,100,150 mg/kg) ,and normal control group was another one. The drugs were chronically administrated to diabetic mice once a day for 21 days. Body weights,MDA levels,SOD activity,insulin levels in serum,fasting blood glucose and glucose tolerance were determined as main indexes. The hypoglycemic effect and mechanism of GSPE in different dose were studied. The results showed that body weights of diabetic mice increased,fasting blood glucose and glucose tolerance levels of diabetic mice in GSPE group of high dose significantly decreased ( P < 0.01); further more MDA levels of diabetic mice decreased, and SOD activities were increased. We concluded that GSPE could significantly decrease blood glucose level, and the mechanism might be related to increase of insulin level and antioxidant activity of diabetic mice.关键词
葡萄籽原花青素提取物/四氧嘧啶/糖耐量/降血糖机制Key words
grape seed proanthocyanidin extracts/alloxan/glucose tolerance/hypoglycemic mechanism分类
医药卫生引用本文复制引用
王颖,张桂芳,徐炳政,姚笛,张东杰..葡萄籽原花青素提取物对糖尿病小鼠血糖的影响[J].天然产物研究与开发,2012,24(9):1191-1195,5.基金项目
黑龙江省基金项目(QC2011C126) （QC2011C126）
黑龙江八一农垦大学博士启动基金项目(校启B-32) （校启B-32）
