天然产物研究与开发2012，Vol.24Issue(9)：1246-1249,4.
肉桂抑制α-葡萄糖苷酶活性成分研究
The Research of α-Glucosidase Inhibitors from Cortex Cinnamomi
摘要
Abstract
To search a-glucosidase inhibitors from Cortex Cinnamomi. The α-glucosidase inhibitor was isolated and purified by the bioactivity-guided method in vitro,combined with HPLC method which was used to analysis the inhibitory activity against a-glucosidase. The inhibitory kinetic of the isolations was also investigated. The petroleum ether extract of Cortex Cinnamomi showed strong inhibitory activity (IC50 =350. 37 μg/mL) .which was higher than that of acarbose ( IC50 = 1028.99 μg/mL) ,and two active compounds were isolated and identified as trans-cinnamaldehyde ( IC50 = 277. 89 μg/mL) and cinnamic acid (IC50 =286.22 μg/mL). Both of them showed noneompetitive type on a-glucosidase with Ki value of 178.07 μg/mL and 229.43 μg/mL,respectively.关键词
肉桂/α-葡萄糖苷酶/高效液相色谱/抑制剂/抑制类型Key words
Cortex Cinnamomi/α-glucosidase/HPLC/inhibitor/inhibitory type分类
医药卫生引用本文复制引用
许芹永,朱靖博,王振中,肖伟..肉桂抑制α-葡萄糖苷酶活性成分研究[J].天然产物研究与开发,2012,24(9):1246-1249,4.基金项目
辽宁省教育厅科学技术研究项目资助(L2010047,L2010052) （L2010047,L2010052）
中药制药过程新技术国家重点实验室资助(SKL2010M0205,SKL2010Z0201) （SKL2010M0205,SKL2010Z0201）
