天然产物研究与开发2012，Vol.24Issue(10)：1393-1397,1423,6.
西洋参茎叶化学成分及生物利用度的研究
Chemical Constituents and Bioavailability of Saponins from the Leaves and Stems of Panax quinquefolium L.
邱楠楠 1刘金平 1艾民 2李平亚1
作者信息
- 1. 吉林大学再生医学科学研究所,长春130021
- 2. 长春大学,长春130022
- 折叠
摘要
Abstract
Ten compounds were isolated from saponins from the leaves and stems of Panax quinquefolium L. by various column ehromatographic techniques. They were elucidated on the basis of physicochemical property and spectral data (TLC.1H and I3C NMR).They were determined as psuedo-ginsenoside-RT4(1) ,psuedo-ginsenoside-RT5(2) ,24(R)-Ocotillol (3) ,20(5)-ginsenoside-Rh, (4) ,20(S)-ginsenoside-Rg, (5) ,20(S)-ginsenoside-Rg2 (6) , 20 ( S)-ginsen-oside-Rh2(7) ,20(R)-ginsenoside-Rh2(8) ,20(S)-ginsenoside-Rg3(9) and psuedo-ginsenoside-PF11 (10). Compounds 1 and 3 were extracted and separated from the leaves and stems of Panax quinquefolium L. for the first time. The bioavailability of intramuscular 20(S)-ginsenoside-Rg3 in dogs were determined and certificated for the first time. In this way,the bioavailability of intramuscular 20(5)-ginsenoside-Rg3 in dogs was determined,which was 96.7%. The results provided the preclinical pharmacokinetics basis for the research and development of 20(S)-ginsenoside-Rg3 injection.
关键词
西洋参茎叶/化学成分/20(S)-人参皂苷Rg3/肌内注射/生物利用度Key words
Panax quinquefolium saponins from leaves and stems/isolation/20(S)-gmsenoside-Rg3/intramuscular injection / bioavailability分类
医药卫生引用本文复制引用
邱楠楠,刘金平,艾民,李平亚..西洋参茎叶化学成分及生物利用度的研究[J].天然产物研究与开发,2012,24(10):1393-1397,1423,6.
