天然产物研究与开发2012，Vol.24Issue(10)：1398-1401,4.
黄芩苷镧(Ⅲ)、钇(Ⅲ)配合物的合成及生物活性研究
Research on Synthesis and Biological Activities of Baicalin-La ( Ⅲ ) 、Y ( Ⅲ ) Complexes
摘要
Abstract
Baicalin-La( Ⅲ) 、Y(Ⅲ) complexes was synthesized by a new method and characterized by IR、UV、LC-MS and metal elemental analysis. Their antimicrobial activity ( Staphylococcus aureus, hay-bacillus, Escherichia cob', salmonella and Candida albicans) and antitumor activity (A549 and HepG2 cells) were tested and compared with baicalin through MTT. The result indicated that the structure of baicalin-La,baicalin-Y complex has changed greatly comparing with baicalin. The acute toxicity testing of mice showed that the compounds had no metal ion toxicity. The bioactivities a-bout antimicrobial efficacy,antitumor efficacy were best for baicalin-La,secondary for baicalin-Y and worst for baicalin.关键词
稀土金属/黄芩苷/配合物/抗菌/抗肿瘤Key words
baicalin/ rare-earth metal/ complexes /antibacterial/ antitumor分类
医药卫生引用本文复制引用
张齐雄,施伦勇,刘衍季..黄芩苷镧(Ⅲ)、钇(Ⅲ)配合物的合成及生物活性研究[J].天然产物研究与开发,2012,24(10):1398-1401,4.基金项目
国家级大学生创新创业训练计划(201210635074) （201210635074）
