武警医学2012，Vol.23Issue(11)：947-949,3.
亲和离心法检测甲胎蛋白异质体在肝癌诊断中的临床应用
The detection of alpha-fetoprotein isoforms using with centrifugal column method in diagnosis of hepatocelluar carcinoma
邸晓辉 1郑绯 2徐娟 1贾志玲 3刘洋4
作者信息
- 1. 100700,北京,北京军区总医院药理科
- 2. 100024,北京,解放军302医院药学部
- 3. 100700,北京,北京军区总医院肿瘤科实验室
- 4. 100039,北京,武警总医院药剂科
- 折叠
摘要
Abstract
Objective To explore the clinical significance of alpha — fetoprotein — L3% ( AFP — L3 ) with centrifugal column method in the diagnosis of hepatocelluar carcinoma . Methods The serum samples of 150 patients with elevated AFP level ( >20 ng/ ml) were detected by chemiluminescence immunoassay for AFP and centrifugal column method for AFP — L3,and the clinical value of AFP — L3 were studied in the differentiation diagnosis of hepatocelluar cancer . Results Taking AFP — L3 >10 ng/ml as the diagnostic criteria,the sensitivity of AFP - L3 was 91. 03% (71/78)in 78 hepatocellular carcinoma patients and the specificity of AFP - L3 was 95. 83% (69/72) in 72 other liver diseases patients. The diagnostic accuracy was 93.33%[(71 +69)/150]. Conclusion Detection of AFP — L3 seemed be of clinical value in benign or malignant liver disease .关键词
甲胎蛋白异质体/肝癌/亲和离心管法Key words
alpha - fetoprotein isoforms/ hepatocelluar/ carcinoma/ centrifugal column method分类
临床医学引用本文复制引用
邸晓辉,郑绯,徐娟,贾志玲,刘洋..亲和离心法检测甲胎蛋白异质体在肝癌诊断中的临床应用[J].武警医学,2012,23(11):947-949,3.
