西安交通大学学报（医学版）2012，Vol.33Issue(6)：719-722,4.
髓过氧化物酶对急性冠状动脉综合征患者的早期临床筛查价值
Early clinical screening value of myeloperoxidase in acute coronary syndrome
马庆华 1邓爱云 2张钲 2刘兴荣 3潘明 2申希平 3白明 2王志禄2
作者信息
- 1. 兰州大学第一医院医务科,甘肃兰州730000
- 2. 兰州大学第一医院心脏中心,甘肃兰州730000
- 3. 兰州大学公共卫生学院流行病与卫生统计学研究所,甘肃兰州730000
- 折叠
摘要
Abstract
Objective To study the early predictive and clinical values of myeloperoxidase (MPO) in acute coronary syndrome (ACS). Methods We enrolled 78 patients with chest pain, including 41 patients with ACS and 17 patients with stable angina pectoris (SAP); the other 20 patients served as controls. The patients were diagnosed according to ACC/AHA guidelines. MPO was measured by enzyme-linked immunosorbent assay (ELISA). Results The level of MPO increased significantly in the ACS patients compared with that in the SAP patients and controls (P<0.05); MPO was higher in the SAP patients than in the controls (P<0.05). MPO, high sensitive C-reactive protein (hs-CRP), neutrophils and ACS cases were higher in patients with MPO≧212. 59 μg/L than in patients with MPO<212. 59 μg/L( P<0. 05). MPO had a positive correlation with neutrophils, creatine kinase isoenzyme, and ACS severity. MPO was not correlated with age, hs-CRP, white blood cell count, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, aspartate aminotransferase, fasting blood glucose, lactate dehydrogenase, red blood cell count, or platelet count. The best cut-off point for MPO was identified as ≧212.59 μg/L using the ROC curve (A = 0.927, P<0.001), revealing elevated sensitivity (95.1%) and specificity (86.5%). Using the Kappa measure, the two diagnostic methods were in good agreement (P<0.001, Kappa value= 0. 819). Logistic regression suggested a high predictive value of MPO in ACS with the total correct rate of 94.9%. Conclusion MPO, an inflammatory marker that can predict the vulnerable plaque, effectively screens ACS at an early stage.关键词
髓过氧化物酶/急性冠状动脉综合征/炎症标志物/筛查Key words
myeloperoxidase/acute coronary syndrome (ACS)/inflammatory marker/screening分类
医药卫生引用本文复制引用
马庆华,邓爱云,张钲,刘兴荣,潘明,申希平,白明,王志禄..髓过氧化物酶对急性冠状动脉综合征患者的早期临床筛查价值[J].西安交通大学学报（医学版）,2012,33(6):719-722,4.
