西安交通大学学报（医学版）2012，Vol.33Issue(6)：773-777,5.
人类乳头瘤病毒16型早期基因178位(T→G)突变分析
Analysis of the point mutation of high risk HPV16 early gene nt178 (T→G)
摘要
Abstract
Objective To detect the point mutation of high risk HPV16 early gene (E6) ntl78(T→G) in cervical cancerous tissues. Methods We detected the point mutation of HPV16 E6 ntl78 in the detected human papillomavirus (HPV) 16 positive cervical cancerous tissues by TDI-FP method so as to explain the correlation between the point mutation and cervical cancer. Results The HPV16 E6 ntl78 (T→G) point mutation rate was 32.5% in the present study. The point mutation rate of HPV16 E6 ntl78 was significantly different from that of the control group (x2 =20.623, P<0.01). Conclusion The point mutation rate of HPV16 E6 ntl78 was higher in our study, which indicates that the point mutation of HPVI6 E6 ntl78 may promote the malignant process in cervical cancer patients and may be one of the cancer risk factors of HPV.关键词
人乳头瘤病毒/宫颈癌/荧光偏振/基因突变Key words
human papillomavirus/cervical cancer/fluorescence polarization/gene mutation分类
医药卫生引用本文复制引用
樊江波,吴静,高艳娥,张菊,张格林,曲群..人类乳头瘤病毒16型早期基因178位(T→G)突变分析[J].西安交通大学学报（医学版）,2012,33(6):773-777,5.基金项目
陕西省科技计划资助项目[No.2007K09-08(2)] （2）
