畜牧兽医学报2012，Vol.43Issue(10)：1664-1668,5.
小型猪特异性麻醉颉颃剂对XFM麻醉下大鼠海马c-jun基因mRNA转录的影响
Effects of the Specificity Antagonist for Miniature Pigs Combined Anaesthetic on the Transcription of c-jun Gene mRNA in the Hippocampus of Rats Anesthetized with XFM
摘要
Abstract
To explore the antagonism mechanism of the specificity antagonist for miniature pigs combined anaesthetic, the effect of the specificity antagonist on the c-jun gene transcription in the hippocampus of rats anesthetized with XFM was studied in this experiment. Ninety adult SD rats were divided randomly into three groups: XFM group, XFM add saline group and XFM add the specificity antagonist group. Each group consists of five subgroups, and samples were collected at different time points. The transcription of c-jun gene mRNA in every sample was detected with real time PCR. The result showed that The c-jun gene mRNA contents in each time point of the XFM group were obviously increased as compared with 0 min (P<C0. 01). There were no signifi-cant effect of injection of saline after XFM administrated on the c-jun gene mRNA transcription (F>0. 05). The level of c-jun gene mRNA transcription after the specificity antagonist adminis-trated was significantly lower than XFM group (P<0. 01 or P<0. 05). These results indicated that the specificity antagonist for miniature pigs combined anaesthetic attenuates the c-jun gene mRNA transcription in the hippocampus of rats induced by XFM, this may be related to the an-tagonism mechanism of the specificity antagonist for miniature pigs' combined Anaesthetic.关键词
小型猪特异性麻醉颉颃剂/海马/c-jun/催醒机制Key words
the specificity antagonist for miniature pigs combined anaesthetic/ hippocampus/ c-jun gene/ the antagonism mechanism分类
农业科技引用本文复制引用
李小波,尹柏双,李志强,石星星,范宏刚,王洪斌..小型猪特异性麻醉颉颃剂对XFM麻醉下大鼠海马c-jun基因mRNA转录的影响[J].畜牧兽医学报,2012,43(10):1664-1668,5.基金项目
国家自然科学基金项目(30671552 （）
30972227) （）
