医药导报2012，Vol.31Issue(10)：1301-1304,4.DOI:10.3870/yydb.2012.10.016
盐酸舍曲林治疗冠心病患者伴焦虑抑郁状态的疗效
Therapeutic Effect of Sertraline on Patients with Coronary Heart Disease Accompanied by Anxiety and Depression
熊荣红 1熊世熙 2张洪1
作者信息
- 1. 武汉大学中南医院神经科、武汉大学第二临床学院神经精神病学教研室,武汉430071
- 2. 武汉大学中南医院心内科,430071
- 折叠
摘要
Abstract
Objective To investigate sertraline hydrochloride on symptoms of anxiety and depression in patients with coronary heart disease. Methods One hundred and seventy-nine cases with coronary heart disease accompanied by anxiety and depression were randomly divided into control group ( 87 cases) and intervention group (92 cases). They were given conventional treatment of coronary heart disease and psychological treatment, and at the same time the intervention group was orally administered with sertraline hydrochloride. Clinical symptoms (ECG ST-segment change, the level of chest pain, etc. ) and the SAS, SDS, SCL-90 scale scores were evaluated after treatment for 2 weeks and 8 weeks, respectively. Results After 8 weeks of treatment, the clinical symptoms in the intervention group (with sertraline hydrochloride) were alleviated significantly with totally efficiency rate (96. 7% ) higher than that in the control group (86. 2% ) (P<0. 05) . After treatment for 2 weeks and 8 weeks, SAS and SDS scores in the intervention group were significantly decreased as compared with those in the control group (P<0.01). In the intervention group, SAS and SDS scores were decreased significantly as compared with those in the control group (P<0. 05) after treatment for weeks. SCL-90 scale result showed that somatization, depression and anxiety status were improved significantly after treatment for 2 weeks and 8 weeks. Conclusion Sertraline can significantly improve anxiety and depression symptoms in patients with coronary heart disease, and significantly alleviate the acute clinical symptoms of patients with coronary heart disease.关键词
舍曲林,盐酸/冠心病/焦虑/抑郁/综合干预Key words
Sertraline, hydrochloride/ Coronary heart disease/ Anxiety/ Depression/ Comprehensive intervention分类
医药卫生引用本文复制引用
熊荣红,熊世熙,张洪..盐酸舍曲林治疗冠心病患者伴焦虑抑郁状态的疗效[J].医药导报,2012,31(10):1301-1304,4.
