医药导报2012，Vol.31Issue(11)：1471-1473,3.DOI:10.3870/yydb.2012.11.027
注射用奥沙利铂纳米结构脂质载体冻干制剂的工艺优选
Optimization of Freeze-drying Process for Preparation of Oxaliplatin Loaded Nanostructured Lipid Carriers for Injection
摘要
Abstract
Objective To investigate the freeze-drying formulations of oxaliplatin in oxaliplatin-loaded nanostuctured lipid carriers( OP-NLC) for injection. Methods The optimum freeze-drying preparation and techniques were established by single factor experiments and the characters were evaluated. Results The optimal freeze-drying technology was determined with 5% of mannitol as protective agent. No significant changes were found in the mean particle size, Zeta potential and EE% , which were (124±6) nm versus ( 115±7) nm,10.8 mV versus 16. 0 mV, and 67. 3% versus 72. 6% post- and pre-freeze-drying, respectively. Conclusion The stable freeze-drying preparation of OP-NLC could be prepared under the optimal condition.关键词
奥沙利铂/纳米结构脂质载体/冻干保护剂/冻干制剂Key words
Oxaliplatin/ Nanostructured lipid carriers/ Cryoprotectant/ Freeze-dried preparation分类
化学化工引用本文复制引用
邱立朋,杨磊,龙苗苗,刘颖,王东凯,周晖..注射用奥沙利铂纳米结构脂质载体冻干制剂的工艺优选[J].医药导报,2012,31(11):1471-1473,3.基金项目
辽宁省沈阳市科学技术计划项目(1091174-1-01) （1091174-1-01）
