应用化学2012，Vol.29Issue(9)：1082-1086,5.DOI:10.3724/SP.J.1095.2012.00458
硝普钠分光光度法测定头孢他啶
Spectrophotometric Determination of Ceftazidime Using Sodium Nitroprusside
摘要
Abstract
A new method is proposed to determine ceftazidime using sodium nitroprusside. In an alkaline solution, a brown product is formed by the reaction of ceftazidime with sodium nitroprusside with the stoichiometric ratio of 1:2. The amount of ceftazidime can be determined owing to the absorbance of the colored product. Absorbency is linear with the concentration of ceftazidime in the range of 2. 50 ~810 mg/L, and the regression equation is A =0. 02704 +0. 00218p( mg/L) with a correlation coefficient of 0. 9987. The apparent molar absorption coefficient and the detection limit are 1. 2 × 10 L/(mol ·cm) and 1. 38 mg/L, respectively. This method is simple and fast, the study indicated that the method could be applied to the determination of ceftazidime in injection with satisfactory results.关键词
硝普钠/头孢他啶/分光光度法Key words
sodium nitroprusside, ceftazidime, spectrophotometry分类
化学化工引用本文复制引用
孙瑶,吴呈珂,李全民..硝普钠分光光度法测定头孢他啶[J].应用化学,2012,29(9):1082-1086,5.基金项目
河南省教育厅自然科学基金资助项目(2008B150011) （2008B150011）
