应用化学2012，Vol.29Issue(11)：1329-1334,6.DOI:10.3724/SP.J.1095.2012.00577
基于金纳米粒子的等离子体共振吸收测定阿莫西林
Determination of Amoxicillin Based on the Plasmon Resonance of Gold Nanoparticles
摘要
Abstract
In pH = 1. 89 Briton-Robinson( BR) buffer, HAuCl4 can be reduced by amoxicillin to form gold nanoparticles, resulting in characteristic plasmon resonance absorption signals at 537 nm and 720 nm. The intensity at 537 nm is proportional to the amoxicillin concentration in a certain range, and amoxicillin can be detected based on the plasmon resonance absorption intensities of the gold nanoparticles. Under the optimized conditions (pH =1. 89, reaction temperature is 65℃ , reaction time is 40 min) , amoxicillin can be detected in the range of 2. 0 × 10 -6 ~ 3. 6 × 10 -5 mol/L with the detection limit of 1. 3 × 10 -7 mol/L. This method has been used in the synthesized samples determination of amoxicillin with the recovery of 90. 4% ~ 103. 2% and a relative standard deviation of less than 4. 6% , then it is applied to the determination of amoxicillin in two commercial capsules with satisfied results compared with HPLC method.关键词
阿莫西林/金纳米粒子/等离子体共振Key words
amoxicillin/ gold nanoparticles/ plasmon resonance分类
化学化工引用本文复制引用
冷飞,李英,甄淑君,李原芳..基于金纳米粒子的等离子体共振吸收测定阿莫西林[J].应用化学,2012,29(11):1329-1334,6.基金项目
国家"重大新药创制"科技重大专项(2010ZX09401-306-1-4)和重庆创新药物孵化基地(2010zx09401-306-1-4)资助项目 （2010ZX09401-306-1-4）
