湖北医药学院学报2012，Vol.31Issue(4)：263-266,封2,5.
胸腺基质淋巴细胞生成素表达与外周血调节性T细胞的相关性
Correlation Between the Expression Level of Thymic Stromal Lymphopoietin and the Treg Cells in Peripheral Blood Mononuclear Cells
摘要
Abstract
Objective To investigate the correlation between the expression level of thymic stromal lymphopoietin ( TSLP) of human thymus tissue and the CD4 + CD25 + Foxp3 + Treg cells in peripheral blood mononuclear cells. Methods The CD4+ CD25 + Foxp3 + Treg cell was tested by flow cytometry from peripheral blood mononuclear cell in 23 patients with congenital heart disease. The expression of TSLP in thymus gland was determined with immunohistochemical staining. The correlation between TSLP expression and CD4 + CD25 + Foxp3 + Treg cell was analyzed by logistic regression. Results The ratio of CD4 + CD25 + Foxp3 + Treg / CD4 + T cell was (5. 73 ± 0. 56) % in 23 patients with congenital heart disease, and expression of TSLP in thymus Hassall's corpuscle was 18. 87 ±3. 06,the logistic regression analysis demonstrated that the expression of TSLP and the phenotype of Treg cells was linear correlated. Conclusion The expression level of TSLP in human thymus is related to the phenotype of the CD4 + CD25 + Foxp3 + Treg cells, and the increasing quantity of Treg cells in peripheral blood may depend on the higher level of TSLP expression.关键词
胸腺组织/胸腺基质淋巴细胞生成素/调节性T细胞/免疫耐受Key words
Thymus gland/Thymic stromal lymphopoietin/Regulatory T cells/Immune tolerance分类
医药卫生引用本文复制引用
王云甫,孙延鹏,孙强,杨超,卢祖能..胸腺基质淋巴细胞生成素表达与外周血调节性T细胞的相关性[J].湖北医药学院学报,2012,31(4):263-266,封2,5.基金项目
湖北省自然科学基金项目(2010CDB09103) （2010CDB09103）
湖北省教育厅重点项目(D20122403) （D20122403）
