原子能科学技术2012，Vol.46Issue(z1)：635-640,6.
细胞尺度10B不均匀分布对细胞微剂量影响的计算与分析
Analysis of Effect on Microdose of 10B Nonuniform Distribution in Cellular
摘要
Abstract
Boron neutron capture therapy (BNCT) is one of the effective way to treat malignant melanoma and head-neck cancer. The intercellular nonuniform distributions of 10B in tumor cell impact the estimates of inactivatibn dose. The a-Li Version 1. 0 code was developed based on Monte-Carlo method to calculate the S values of cell induced by a and 7Li particle which are the products of 10B(n,a)7Li. The calculation included two types of cell size, eight kinds of energy of a particle and three kinds of source distributions. Differences between results of this code and an analytical algorithm of MIRD committee were within 1%. On this basis, a total of 3 420 cases were calculated and analyzed with different kinds of nucleus radius, cell radius, and source launch position combination. Finally, cellular S values of 10B(n,a)7Li calculated in this paper can be used to compute the excellent precision dose under 10B compound nonuniform distribution in intercellular scale.关键词
微剂量/硼中子俘获治疗/蒙特卡罗方法/细胞核Key words
microdosimetry/ boron neutron capture therapy/ Monte-Carlo/ nucleus分类
医药卫生引用本文复制引用
谢芹,耿长冉,汤晓斌,陈达..细胞尺度10B不均匀分布对细胞微剂量影响的计算与分析[J].原子能科学技术,2012,46(z1):635-640,6.基金项目
江苏省博士后科研资助计划项目资助(1002012C) （1002012C）
