中国病理生理杂志2012，Vol.28Issue(11)：1921-1927,7.DOI:10.3969/j.issn.1000-4718.2012.11.001
短链酰基辅酶A脱氢酶在大鼠生理性和病理性心肌肥大中的作用
Effect of short-chain acyl-CoA dehydrogenase on cardiac hypertrophy induced by hypertension or exercise training
摘要
Abstract
AIM: To investigate the differential expression of short - chain acyl - CoA dehydrogenase ( SCAD) in cardiac hypertrophy induced by hypertension or exercise training. METHODS: Spontaneously hypertensive rats (SHR) were used as the model of pathological cardiac hypertrophy. The swim - trained rats were used as the model of physiological cardiac hypertrophy. The systolic pressure, cardiac hypertrophy parameters, echocardiogram parameters, free fatty acid in serum and cardiac muscle, and the expression and activity of SCAD in the left ventricle were measured. RESULTS: Com-pared with the control rats, trained rats developed an athletic heart, of which cardiac function was enhanced, whereas SHR developed hypertensive cardiac hypertrophy, of which cardiac function was deteriorated. Compared with the control rats, the ratios of left ventricular weight to body weight were both increased in trained rats and SHR, showing that the degrees of cardiac hypertrophy were similar in the 2 models. Compared with the control rats, the decrease of free fatty acid both in ser-um and myocardium indicated that the fatty acid utilization was increased in the left ventricle of trained rats. Meanwhile, the expression and activity of SCAD in the left ventricle of trained rats were increased. However, free fatty acid both in ser-um and myocardium were increased, indicating that the fatty acid utilization was decreased in the left ventricle of SHR. Furthermore, SHR had the decreased expression and activity of SCAD in the left ventricle. CONCLUSION: The changes of SCAD are different in cardiac hypertrophy induced by hypertension and exercise training, indicating that SCAD may be used as a molecular marker of physiological and pathological cardiac hypertrophy, and a potential therapeutic target of path-ological cardiac hypertrophy.关键词
心肌肥大/高血压/运动/短链酰基辅酶A脱氢酶/脂肪酸氧化Key words
Cardiac hypertrophy/Hypertension/Exercise/Short-chain acyl-CoA dehydrogenase/Fatty acid oxidation分类
医药卫生引用本文复制引用
周四桂,王平,路遥,袁茜,潘雪刁,金桂芳,徐立朋..短链酰基辅酶A脱氢酶在大鼠生理性和病理性心肌肥大中的作用[J].中国病理生理杂志,2012,28(11):1921-1927,7.基金项目
国家自然科学基金青年科学基金资助项目(No.81000072 （）
No.81001683) （）
教育部留学回国启动基金资助项目(No.23610008) （No.23610008）
教育部博士学科点专项科研基金资助项目(No.20104401120003) （No.20104401120003）
广东药学院重点培养青年教师资助项目 （）
广东省"十二五"医学重点学科(依托广东药学院附属第一医院、药科学院) （依托广东药学院附属第一医院、药科学院）
