粒细胞集落刺激因子联合缺血后适应治疗急性心肌梗死的实验研究OA北大核心CSCDCSTPCD
Cardiac protective effect of granulocyte colony-stimulating factor combined with ischemic postconditioning on acute myocardial infarction in rabbits
目的:探讨粒细胞集落刺激因子(G-CSF)联合缺血后适应(IP)对实验兔急性心肌梗死的心脏保护作用.方法:将兔结扎左室支(LVA)后分为4组:缺血再灌注模型组(IR组,松结后直接再灌注)、G-CSF组(松结并于术后12 h开始使用G-CSF皮下注射)、IP组(予以IP行改良再灌注)和G-CSF + IP组(联合应用IP及G-CSF干预).观察各组术中心电图ST段变化,检测手术前后血常规和心肌钙蛋白I(cTnI),术后4周行超声心动图检查,测定各组…查看全部>>
AIM; To investigate the protective effect of granulocyte colony - stimulating factor (G - CSF) combined with ischemic postconditioning (IP) on acute myocardial infarction ( AMI). METHODS: Male New Zealand rabbits were randomly divided into 4 groups ( n = 15 ) after 30 min of left ventricular artery ( LVA) occlusion: the rabbits in ischemia - reperfusion (IR) group were directly given reperfusion; the rabbits in G - CSF group were subsequently treated with G …查看全部>>
于宗良;陈乐;杨向军
江苏大学附属昆山医院心内科,江苏,昆山,215300苏州大学附属第一医院心内科,江苏,苏州,215006苏州大学附属第一医院心内科,江苏,苏州,215006
医药卫生
粒细胞集落刺激因子缺血后适应心肌梗死再灌注损伤
Granulocyte colony-stimulating factorIschemic postconditioningMyocardial infarctionReper-fusion injury
《中国病理生理杂志》 2012 (11)
1933-1937,5
昆山市科技局计划项目(No.KS1002)
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