中国当代儿科杂志2012，Vol.14Issue(9)：683-688,6.
T淋巴细胞毒相关抗原-4基因49位点多态性与儿童1型糖尿病相关性的Meta分析
Association of cytotoxic T lymphocyte-associated antigen-4 + 49A/G polymorphism with childhood type 1 diabetes mellitus: a meta-analysis
罗淑颖 1谭利娜 2卫海燕 1张耀东 1陈永兴1
作者信息
- 1. 郑州市儿童医院内分泌科,河南郑州450052
- 2. 郑州市儿童医院心脏外科,河南郑州450052
- 折叠
摘要
Abstract
Objective To evaluate the association of cytotoxic T lymphocyte-associated antigen-4 ( CTLA4) + 49A/G polymorphism with type 1 diabetes mellitus (T1DM) in children. Methods Papers about the association of CTLA4 +49A/ G polymorphism with Tl DM in children were collected by searching PubMed, EBSCO, CBM, CNKI, and Wanfang Data. A meta-analysis was performed to examine differences in the genotypes (AG, GG, and GG + AG) and G allele at position 49 of the CTLA-4 gene between a childhood T1DM group and a control group. Results A total of 10 papers involving 1084 T1DM children and 1338 healthy children were included. The Meta-analysis was performed to evaluate the association of the genotypes (AG, GG, and GG + AG) and the G allele at position 49 of the CTLA4 gene with T1DM using a fixed effect model according to the heterogeneity test results of all studies. The pooled OR values (95% CI) were 1.13 (0. 97-1. 33) , 1.42 (1. 16-1.75) , 1.20 (1.03-1.40) , and 1.21 (1.09-1.33) , suggesting a significant difference in genotypes (AG, GG, and GG +AG) and the G allele at position 49 of the CTLA4 gene between the two groups. Conclusions CTLA4 + 49A/G polymorphism is associated with T1DM in children.关键词
Meta分析/T淋巴细胞毒相关抗原-4基因/1型糖尿病/基因多态性/儿童Key words
Meta-analysis/Cytotoxic T lymphocyte-associated antigen^- gene/Type 1 diabetes mellitus/Genetic polymorphism/Child分类
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罗淑颖,谭利娜,卫海燕,张耀东,陈永兴..T淋巴细胞毒相关抗原-4基因49位点多态性与儿童1型糖尿病相关性的Meta分析[J].中国当代儿科杂志,2012,14(9):683-688,6.
