中国肺癌杂志2012，Vol.15Issue(9)：513-520,8.DOI:10.3779/j.issn.1009-3419.2012.09.03
晚期非小细胞肺癌表皮生长因子受体基因突变情况和其对吉非替尼疗效的影响
EGFR Gene Mutation Statuses in Advanced Non-small Cell Lung Cancer Patients and Their Influence on Effect of Gefitinib
钟巍 1王孟昭 1李龙芸 1夏莹 1陈闽江 1张力 1赵静1
作者信息
- 1. 100730 北京,中国医学科学院北京协和医学院北京协和医院呼吸内科
- 折叠
摘要
Abstract
Background and objective It has been proven that the status of epidermal growth factor receptor (EGFR) gene mutation was related to effects of gefitinib in patients with advanced non-small cell lung cancer (NSCLC). The aim of this study is to reports distribution of EGFR gene mutations in advanced NSCLC and their influence on effect of gefitinib. Methods From Jan 2007 to Dec 2009, 160 patients with advanced non-squamous NSCLC received EGFR mutation tests, and EGFR exon 19 and 21 were amplified by mutant-enriched PCR and analyzed by sequencing. Among those patients, 111 received gefitinib therapy. Overall survival (OS) and progression free survival (PFS) were calculated using the Kaplan-Meier method and a Cox regression analysis was used to detect differences between strata. Results The percentage of EGFR mutation in advanced non-squamous NSCLC was 55%, and it was only significantly related with pathological type. OS of the patients with or without EGFR gene mutations were 29.0 months (95%CI: 24.2-33.8) and 21.0 months (95%CI: 14.7-27.3) respectively, and the difference was not significant. PFS of patients with or without EGFR gene mutations were 17.0 months (95%CI: 5.6-17.6) and 11.6 months (95% CI 8.6-25.4), and the difference was significant (P=0.022). Multi-variate analysis shows that OS was significantly related with ECOG status, pathological type and EGFR mutation statuses, and PFS was significantly related to ECOG status, former regimens number and EGFR mutation statuses. There were no significant differences in OS and PFS between patients with EGFR exon 19 deletions and those with exon 21 point mutation. Conclusion PFS of patients with EGFR mutations was better than those without EGFR mutations, but OS was similar. There were no significant differences in OS and PFS between patients with EGFR exon 19 deletions and those with exon 21 point mutation.关键词
肺肿瘤/表皮生长因子受体/突变/吉非替尼Key words
Lung neoplasms/ Epidermal growth factor receptor/ Mutation/ Gefitinib分类
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钟巍,王孟昭,李龙芸,夏莹,陈闽江,张力,赵静..晚期非小细胞肺癌表皮生长因子受体基因突变情况和其对吉非替尼疗效的影响[J].中国肺癌杂志,2012,15(9):513-520,8.
