局解手术学杂志2012，Vol.21Issue(5)：527-528,530,3.
FAP-1和RAC-1在原发性胰腺癌组织中的表达及其临床意义
Expressions of FAP-1 and RAC-1 in primary pancreatic cancer and their clinical significances
王青 1赵华栋 1阴继凯 1董瑞 1鲁建国1
作者信息
- 1. 第四军医大学唐都医院普通外科,陕西西安710038
- 折叠
摘要
Abstract
Objective To investigate the expressions of fas-associated phophatase-1 (FAP-1) and ras-related C3 botulinum toxin sub-strace-1 (RAC-1) in primary pancreatic cancer (PPC) and their associations with the metastasis of PGC. Methods The expressions of FAP-1 and RAC-1 in PPC tissues (n =40) were detected by immunohistochemistry. The relationship between the expressions and the invasion and metastasis of PPC was analyzed. Results The expressions of FAP-1 and RAC-1 in PPC were significantly higher than those in normal pancreatic tissue ( P < 0. 01) and the expressions of RAC-1 were correlated with those of FAP-1 (P < 0.05 ). The expressions of FAP-1 and RAC-1 were significantly higher in lymph node metastasis than those without lymph node metastasis (P<0.05). There was no correlation between the positive expressions of FAP-1 and RAC-1 and the histopathologieal classification in pancreatic cancer (P >0.05). Conclusion The expressions of FAP-1 and RAC-1 in PPC may reflect the metastasis of PPC and joint detection of the expressions of two proteins is of certain clinical significance in the diagnosis of pancreatic cancer.关键词
原发性胰腺癌/Fas相关磷酸酯酶1/RAC-1/肿瘤转移Key words
primary pancreatic cancer/fas-associated phosphatase-1 /ras-related C3 botulinum toxin substrate-1/tumor metastasis
分类
医药卫生引用本文复制引用
王青,赵华栋,阴继凯,董瑞,鲁建国..FAP-1和RAC-1在原发性胰腺癌组织中的表达及其临床意义[J].局解手术学杂志,2012,21(5):527-528,530,3.
