局解手术学杂志2012，Vol.21Issue(6)：647-649,3.
神经外科手术患者应用氟喹诺酮类药抗感染疗效的影响因素
Analysis of influencing factors for anti-infection efficacy of fluoroquinolones in neurosurgical patients
唐宗椿 1王晓峰 1杨兴奎 1张荣军1
作者信息
- 1. 解放军第三医院神经外科,陕西宝鸡721004
- 折叠
摘要
Abstract
Objective To analyze the influencing factors of therapeutic efficacy of antibacterial fluoroquinolones in neurosurgical patients, and to provide reference for rational use of fluoroquinolones in clinic. Methods The scale of influencing factors for 133 neurosurgical patients who treated with fluoroquinolones , including age, gender, liver and renal function index, and other factors, were designed and filled according to the data of clinical case. The data were analyzed through Logistic regression analysis to determine the main factors that influenced therapeutic effects. Results In 133 cases,pathogens were cultured by microbial test in 16 cases (12. 03% ). Among influencing factors of therapeutic efficacy of fluoroquinolones, the age, gender, creatinine, alanine aminotransferase and aspartate aminotransferase were major factors. Logistic regression analysis showed that the OR values were from 0. 029 to 5. 317 and P values from 0. 003 to 0.026. Conclusion The results suggest that elderly and poor liver and kidney function patients using fluoroquinolones as anti-infective therapy are ineffective. Fluoroquinolone drugs for the elderly and liver and kidney dysfunction patients with anti-infective therapy, individual therapy should be based on susceptibility testing and changes in condition.关键词
术后感染/氟喹诺酮类/疗效/影响因素/Logistic同归分析Key words
postoperative infection/ fluoroquinolones/ therapeutic efficacy/ influencing factors/ Logistic regression analysis分类
医药卫生引用本文复制引用
唐宗椿,王晓峰,杨兴奎,张荣军..神经外科手术患者应用氟喹诺酮类药抗感染疗效的影响因素[J].局解手术学杂志,2012,21(6):647-649,3.
