中国临床药理学与治疗学2012，Vol.17Issue(9)：1010-1014,5.
多元回归模型对泽泻调脂颗粒组方的定量评价
The quantitative evaluation of the Zexie Tiaozhi granule formulation through multiple regression model
摘要
Abstract
AIM: The nonlinear mixed effect model (NONMEM) -was applied in the analysis of Traditional Chinese Medicine (TCM) formula , based on the data of different compatibility of Zexie Tiaozhi granule in treatment of hyperlipi-demia rat model. The compatible regularity of Zexie Tiaozhi granule was evaluated quantitatively and the result can be used as a reference to formula optimization. METHODS: The four main compositions of Zexie Tiaozhi granule were combined in uniform design and analyzed by NONMEM. The TG in serum was treated as the pharmacodynamics index. RESULTS: Final model suggested that X1 was the primary effective composition and X3 was an antagonistic composition. The dose-effect relationship of X2 and X4 was not clear, and the efficacy was mainly expressed in the interaction between compositions. Based on the above, we recommended that the formula will perform maximum efficacy when X1 , X2 and X4 take the maximum dose and X3 take the minimum dose. CONCLUSION: The application of NONMEM in analysis of TCM formula can investigate the interactions among compositions and the random effects like inter individual and intra individual variations comprehensively, which can provide vast quantities of information.关键词
多元回归/非线性混合效应/最优组方/模拟Key words
Multiple regression/ Nonlinear mixed effect model/ Formula optimization/ Simulation分类
医药卫生引用本文复制引用
黄继汉,尹芳,李云飞,何迎春,张密,刘成海,刘红霞..多元回归模型对泽泻调脂颗粒组方的定量评价[J].中国临床药理学与治疗学,2012,17(9):1010-1014,5.基金项目
国家科技支撑计划项目(2008BAI51B03) （2008BAI51B03）
上海市教委重点学科项目(J50303) （J50303）
上海市高校E研究院项目(E03008) （E03008）
