中国临床药理学与治疗学2012，Vol.17Issue(9)：1033-1037,5.
不同剂量阿托伐他汀对2型糖尿病患者心血管并发症的影响
Effect of different doses of atorvastatin on cardiovascular complications in patients with type 2 diabetes
李银 1黎敬锋 1李世光 1王厚阳 1王超 1陈良余 1陆明奎 1蔡大炜1
作者信息
- 1. 安徽省滁州市第二人民医院心内科,滁州239000,安徽
- 折叠
摘要
Abstract
AIM: To investigate the effect of different doses of atorvastatin on cardiovascular complications in patients with type 2 diabetes. METHODS: 150 cases of type 2 diabetes patients were randomly divided into three groups, control group, conventional lipid-lowering group (atorvastatin 20 mg/d) , intensive lipid-lowering group 50 cases (atorvastatin 40 mg/d) (n= 50). The conventional therapies in three groups including antiplatelet therapy and hypoglycemic therapy (drugs and/or insulin). All groups were followed up for 3 years, investigate the effect between three groups in cardiovascular complications. RESULTS: Compared with control group, after treatment, the levels of TC and LDL-C were decreased and the levels of HDL-C were increased in conventional lipid-lowering group and intensive lipid-lowering group(P<0. 01). After treatment, the TC, LDL-C decreased level and the HDL-C elevated level between conventional lipid-lowering group and intensive lipid-lowering group showed significantly difference ( P < 0.01). Compared with the control group, the proportion of major cardiovascular complications in 3 years was decreased significantly in the intensive lipid-lowering group and conventional lipid-lowering group(P<0. 05). Compared with the conventional lipid-lowering group, the proportion of cardiovascular complications in the intensive lipid-lowering group was decreased significantly (P<0. 05). CONCLUSION: Atorvastatin can decrease the cardiovascular complications in patients with type 2 diabetes, the effect of intensive lipid-lowering is better, and has no adverse reaction.关键词
阿托伐他汀/2型糖尿病/心血管并发症/影响Key words
Atorvastatin/ Type 2 diabetes mellitus/ Cardiovascular complication分类
医药卫生引用本文复制引用
李银,黎敬锋,李世光,王厚阳,王超,陈良余,陆明奎,蔡大炜..不同剂量阿托伐他汀对2型糖尿病患者心血管并发症的影响[J].中国临床药理学与治疗学,2012,17(9):1033-1037,5.
