中国临床药理学与治疗学2012，Vol.17Issue(9)：1047-1051,5.
利培酮口服液与奥氮平治疗脑器质性精神障碍疗效与安全性分析
A retrospective study of risperidone oral solution versus olanzapine tablets in treating brain organic mental disorders
摘要
Abstract
AIM: To retrospectively evaluate the efficacy and safety of risperidone oral solution and olanzapine tablets in treating brain organic mental disorders. METHODS: A total of 133 patients, who met diagnostic criteria of CC~ MD-3 for brain organic mental disorders and were hospitalized in department of psychiatry from May 2007 to May 2011, included 62 patients in risperidone oral solution group and 71 patients in olanzapine tablets group. On the pre-treatment and at the end of the 4th week of treatment, all patients were assessed by Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS), Scale for the Assessment of Positive Symptoms (SAPS) , Treatment Emergent Symptom Scale (TESS) and laboratory tests. RESULTS: There were significant difference in extrapyramidal side effects, prolactin levels, sleepiness and weight gain between pre-treatment and post-treatment (32.3% vs 16. 9%, 19.4% vs 5. 6%, 6. 5% vs 19. 7%, 9.7% vs 19. 6%, P<0. 05) . However, there were no statistically significant difference (P>0.05) in the total scales of BPRS, SANS, SAPS , TESS and other index of safety. CONCLUSION; The efficacy of risperidone oral solution and olanzapine tablets in treating brain organic mental disorders was equal, especially for mental disorder due to encephalitis the efficacy up to about 80%, but there were some differences in side effects. It was needed to arrange the treating program according to the patients conditions.关键词
脑器质性精神障碍/利培酮口服液/奥氮平/副反应量表Key words
Brain organic mental disorders -, Risperidone oral solution/ Olanzapine tablets/分类
医药卫生引用本文复制引用
钟智勇,张明,王继辉,吴小立..利培酮口服液与奥氮平治疗脑器质性精神障碍疗效与安全性分析[J].中国临床药理学与治疗学,2012,17(9):1047-1051,5.基金项目
广东省计划项目(2009B080701080) （2009B080701080）
