中国临床药理学与治疗学2012，Vol.17Issue(9)：1067-1074,8.
CYP2D6基因多态性与抗精神病药物的个体化应用
Genetic polymorphism of CYP2D6 and its influence on the personalized usage of antipsychotics
陈冰 1蔡卫民 2杨婉花1
作者信息
- 1. 上海交通大学医学院附属瑞金医院药剂科,上海200025
- 2. 复旦大学药学院临床药学系,上海201203
- 折叠
摘要
Abstract
CYP2D6 is one of the most important cytochrome P450 enzymes. There is remarkable genetic polymorphism of CYP2D6. CYP2D6 play an important role in the metabolism of antipsychotics, and has significant correlation with the inter-individual difference ol pharmacokinetics and pharmacodynamics of antipsychotics. Determination of CYP2D6 genotypes is helpful in the selection and regulation of antip-sychotic therapy regimen for the elevation of ef-ficiency and safety. The influence of CYP2D6 genetic polymorphism on the pharmacokinetics, adverse effect and drug-drug interaction was reviewed and the usefulness of CYP2D6 genoty-ping in the personalized antipsychotic therapy was discussed关键词
CYP2D6/基因多态性/抗精神病药物/药动学/不良反应Key words
CYP2D6/ Genetic polymorphism/ Antipsychotics/ Pharmacokinetics/ Adverse drug reaction分类
医药卫生引用本文复制引用
陈冰,蔡卫民,杨婉花..CYP2D6基因多态性与抗精神病药物的个体化应用[J].中国临床药理学与治疗学,2012,17(9):1067-1074,8.
