中国临床药理学杂志2012，Vol.28Issue(10)：723-725,3.
宫腹腔镜联合检查患者应用帕瑞昔布钠的镇痛效果和满意度
Efficacy of parecoxib on pain management and patients' satisfactory after diagnostic hysteroscopy and laparoscopy
刘慧丽 1李跃新 2李萍 1李民1
作者信息
- 1. 北京大学第三医院,麻醉科,北京100191
- 2. 北京大学第三医院,生殖医学中心,北京100191
- 折叠
摘要
Abstract
Objective To assess the effect of preoperative administration of parecoxib on anesthesia recovery, pain management and patients' satisfactory after diagnostic hysteroscopy and laparoscopy. Methods Sixty patients undergoing elective diagnostic hysteroscopy and laparoscopy, were enrolled in the randomized, placebo - controlled, double - blind trial. After anesthesia induction, patients were randomly assigned to receive 40 mg of intravenous parecoxib (group D; n = 30) or an equal volume of saline (group S; n = 30) . Assessments included recovery time to eye opening, response to commands and orientation. Postoperative outcomes included postoperative analgesic consumption and pain scores, occurrence of nausea and vomiting and patient satisfaction. Antiemetic requirements and adverse effects were noted during the first postoperative 24 h. Results The most serious and most slight pain scores were significantly lower in the parecoxib group compared with those of the placebo group during the first postoperative 24 h (3. 9 ± 3. 8 vs 5. 6 ± 4. 6, P < 0. 05, and 0.5 ± 1. 4 vs 1. 4 ± 1. 8, P < 0. 05 ). The number of patients receiving tramadol (6 versus 1, P < 0. 05 ) was greater in group S than that in group D. There were no differences between the two groups in recovery time, antiemetic requirements, or adverse effects after surgery. Overall satisfaction with pain management was higher in parecoxib - treated patients. Conclusion Perioperative use of parecoxib provides a significant
analgesic benefit in patients undergoing diagnostic hysteroscopy and laparoscopy.关键词
帕瑞昔布钠/宫腹腔镜联合检查/疼痛Key words
parecoxib/ diagnostic hysteroscopy and laparoscopy/ pain分类
医药卫生引用本文复制引用
刘慧丽,李跃新,李萍,李民..宫腹腔镜联合检查患者应用帕瑞昔布钠的镇痛效果和满意度[J].中国临床药理学杂志,2012,28(10):723-725,3.
