中国临床药理学杂志2012，Vol.28Issue(10)：746-748,3.
阿芬太尼对单肺通气患者肿瘤坏死因子-α与白细胞介素-6的影响
Effects of alfentanil on tumor necrosis factor-α and interleukin-6 in patients undergoing one lung ventilation
摘要
Abstract
Objective To investigate the effects of alfentanil on TNF -α, interleukin - 6 and their mRNA in patients undergoing one lung ventilation (OLV). Methods Twenty - four patients with lung cancer resection were randomly divided into two groups ( n = 12 each) : group I fenta-nyl and group II alfentanil. Anesthesia was induced with midazolam 0. 03 mg ? Kg-1 , fentanyl 3 μg ? Kg-1 (or alfentanil 18 μg ? Kg-1 ) and 8% sevoflurane, and maintained with intermittent iv boluses of vecuronium 0. 04 -0. 08 mg ? Kg-1, fentanyl 0. 05 - 0. 10 mg ( or alfentanil 0. 3 -0. 6 mg) . Blood sample were taken before skin incision (T0) , 60 min after OLV (T1) , 60 min after lungs were inflated (T2 ) for determination of plasma TNF - α, IL - 6 concentration and expression of their mRNA. Results The levels of TNF - α, IL - 6 and their mRNA were all significantly increased at T 1, T 2 in both groups ( P < 0. 05 ) . The levels of,TNF -α, IL -6 and their mRNA were lower in group alfentanil than those in group fentanyl at T 1 and T 2 (P < 0. 05). Conclusion Alfentanil is effective in inhibiting the production of pro - inflammatory cyto kine for patients undergoing OLV.关键词
阿芬太尼/单肺通气/肺癌/肿瘤坏死因子-α/白介素-6Key words
alfentanil/ one lung ventilation/ lung cancer/ tumor necrosis factor - α/ interleukin - 6分类
医药卫生引用本文复制引用
李兆国,范金鑫,帅训军,崔宏先,艾登斌..阿芬太尼对单肺通气患者肿瘤坏死因子-α与白细胞介素-6的影响[J].中国临床药理学杂志,2012,28(10):746-748,3.基金项目
青岛市卫生局基金资助项目(2010-WSZD004) （2010-WSZD004）
