中国临床药理学杂志2012，Vol.28Issue(10)：770-772,3.
药物个体效应及其图形化评价
Dissection of drug individual response and its plotting evaluation
摘要
Abstract
Objecitve To evaluate the performance of models and graphic tool in understanding of the individual response for individual therapy. Methods The individual response was dissected by mathematical model combined with the covariate effects and random error. The results were also expressed by plotting. Results The individual response is composed of 4 components including typical effect, covariate effect, interin-dividual - random effect and intraindividual - random effect. These components can be identified and expressed quantitatively by the parameters using some mathematical method with graphic method. Conclusion An individual therapy may obtain an individual response. Modeling method and graphic tools helps to understand this concept and its quantitative expression.关键词
个体效应/模型化/图形化/随机效应/固定效应Key words
individual response/ modeling/ plotting expression/ random effects/ fixed effects分类
医药卫生引用本文复制引用
黄继汉,尹芳,王鲲,何迎春,刘成海,郑青山..药物个体效应及其图形化评价[J].中国临床药理学杂志,2012,28(10):770-772,3.基金项目
国家科技支撑计划基金资助项目(2008BAI51B03) （2008BAI51B03）
上海市教委重点学科基金资助项目(J50303) （J50303）
上海市高校E研究院基金资助项目(E03008) （E03008）
上海市教委创新基金资助项目(10YZ61) （10YZ61）
