中国临床药理学杂志2012，Vol.28Issue(10)：779-781,3.
广义可加模型在H1N1疫苗效果评估中的应用
Application of generalized additive model in immunogenicity evaluation of H1N1 vaccine
摘要
Abstract
Objective To discuss the advantage of generalized additive models in dealing with nonlinear data. Methods By applying generalized additive models and general linear models to the data containing nonlinear variable from clinic trail of H1N1 vaccine, the associated factors of H1N1 titer were analyzed. Results Comparing with general linear models , the goodness of fit of GAMs with less deviation and mean squared error is better. Conclusion Dealing with the nonlinear data, GAMs perform better than general linear models, suggesting that GAMs should be chosen under such circumstance.关键词
广义可加模型/一般线性模型/非线性Key words
generalized additive models/ general linear models/ nonlinear分类
医药卫生引用本文复制引用
张润华,王建生,马林茂..广义可加模型在H1N1疫苗效果评估中的应用[J].中国临床药理学杂志,2012,28(10):779-781,3.基金项目
环境与健康风险评估基本数据集与信息共享关键技术资金资助项目(201209046) （201209046）
