中国临床医学2012，Vol.19Issue(4)：339-342,4.
信号转导转录激活因子3抑制剂WP1066对肝细胞肝癌生物学特性影响的研究
Effects of an Inhibitor of Signal Transducer and Activator of Transcription 3, WP 1066, on the Biological Characteristics of Hepatocellular Carcinoma
摘要
Abstract
To explore the effects of an inhibitor of signal transducer and activator of transcription 3 (STAT3), WP1066, on the proliferation and invasion of hepatocellular carcinoma (HCC) cells in vitro and in vivo. Methods: The expression level and phosphorylation level of STAT3 in HCC cell lines with different malignant potential were detected by Western blotting and Transwell method. The antitumor activities of WP1066 and related mechanisms were studied in HCC cell line MH-CC-97H and also in a subcutaneous HCC model in nude mice. Results; STAT3 phosphorylation level was significantly higher in HCC cell lines with higher malignant potential. WP1066 significantly inhibited cell proliferation and invasion in MHCC-97H. WP1066 also significantly inhibited the growth of tumor in nude mice HCC model. Conclusions: WP 1066 can suppress the proliferation and invasion of HCC through inhibition of the phosphorylation level of STAT3.关键词
肝癌/抑制剂/信号转导转录激活因子3/增殖/侵袭Key words
Hepatocellular carcinoma/ Inhibitor/ Signal transducer and activator of transcription 3/ Proliferation/ Invasion分类
医药卫生引用本文复制引用
张巨波,郭坤,陈漪,葛宁灵,任正刚..信号转导转录激活因子3抑制剂WP1066对肝细胞肝癌生物学特性影响的研究[J].中国临床医学,2012,19(4):339-342,4.基金项目
国家自然科学基金资助项目(编号:30872505、81172275) （编号:30872505、81172275）
