摘要
Abstract
Objective: To observe the clinical value of early diagnosis of atherosclerosis in patients with systemic lupus erythematosus (SLE) using wave intensity technique and to evaluate changes of elasticity of carotid artery in pre—menopausal SLE patients. Materials and Methods: Sixty patients with SLE were divided into two groups according to different clinical courses: SLE group l(duration<5 years), and SLE group 2 (duration ≥ 5 years). A Wave intensity method was used to measure and analyze instantaneous acceleration Wave intensity (W1), instantaneous deceleration Wave intensity (W2), negative area(NA), stiffness constant(β), one-point pulse wave velocity(PWVβ and PWV-WI), pressure strain elastic modulus(Ep), arterial compli-ance(AC), augmentation index (AI) and intimamedia thickness (IMT) of the right carotid arteries in 60 patients with SLE and in 30 normal control individuals. Results: Compared with the normal group, W2, β, Ep, PWV-WI, PWVβ of SLE group 1 and SLE group 2 were higher than those of the control group, but AC was lower than that of the control, with a statistically significant difference(P^0.01). W1; AI, NA values were different in the three groups, but the difference was not statistically significant (P>0.01). W2, PWV-WI, P, Ep, PWVβ significantly increased in SLE group 2 comparing with SLE group 1, but AC decreased, with a statistically significant difference(P≤0.01). Conclusion: WI technique can detect the early changes of carotid elasticity in systemic lupus erythematosus patients. It may be useful for prevention and treatment of the complicated cardiovascular disease.关键词
红斑狼疮,系统性/颈动脉/弹性/超声检查Key words
Lupus erythematosus, systemic/ Carotid arteries/ Elasticity/ Ultrasonography分类
医药卫生
