中国临床药学杂志2012，Vol.21Issue(5)：291-295,5.
注射用盐酸吉西他滨与4种临床常用输液的配伍稳定性
Compatible stability of gemcitabine hydrochloride for injection with four common clinical infusion fluids
摘要
Abstract
AIM To establish a method for the determination of gemcitabine hydrochloride and to assess the stability of gemcitabine hydrochloride for injection with the four common clinical infusion fluids. METHODS The contents of gemcitabine hydrochloride in the different fluids (0.9% sodium chloride injection, 5% dextrose injection, glucose and sodium chloride injection and sodium lactate ringer's injection) were determined at different temperature and light condition of (4 500 ± 500)Lx by HPLC at different time points. The outward appearance, color variety and pH value were investigated as well. RESULTS Within 24 h, the contents, the outward appearance or the pH value of gemcitabine hydrochloride had no apparent changes at 25 and 30℃; after 24 h, the contents decreased by 5% at average, the pH value increased slightly at 40℃; after 10 days, the contents decreased by 4% at average, the pH value increased slightly at (4 500 ± 500) Lx. Otherwise, in the same condition the contents of gemcitabine hydrochloride in Gemzar fluids was little higher than in Yujie fluids. CONCLUSION Gemcitabine hydrochloride for injection are chemically stable in the four fluids, but in the condition of 40℃ and light it must be used carefully after a long time delay.关键词
盐酸吉西他滨/高效液相色谱/配伍稳定性/热稳定性/光照稳定性Key words
gemcitabine hydrochloride/ HPLC/ compatibility/ thermostability/ photostability引用本文复制引用
郭彦琨,张渊,刘皋林,朱冠华,张英..注射用盐酸吉西他滨与4种临床常用输液的配伍稳定性[J].中国临床药学杂志,2012,21(5):291-295,5.基金项目
上海市药学会科研基金(编号2010-YY-01-07) （编号2010-YY-01-07）
