中国美容医学2012，Vol.21Issue(15)：1964-1966,3.
人牙周细胞压力作用下Hif-1 alpha及Rankl/Opg变化
The expression of Hif-1 alpha and Rankl/Opg in human periodontal ligament cells under compressure
郭莉 1徐静 2郭宏刚3
作者信息
- 1. 西安市第九医院口腔科 陕西 西安 710054
- 2. 西安市第二医院口腔科
- 3. 西安市武警工程大学医院骨科
- 折叠
摘要
Abstract
Objective To determine the expression of Hif-1 alpha and Rankl/Opg mRNA in in vitro human periodontal ligament fibroblast pellets subjected to overloaded pressure. Methods Constructed human periodontal ligament fibroblast pellets were grouped into 0.2 Mpa, 4 h compressure group and untreated control group and the mRNA level of Hif-1 alpha, Rankl and Opg was detected by real-time RT-PCR. Results Hif-1 alpha and Rankl mRNA were significantly increased in compressure group and the compressure downregulated the Opg mRNA. Conclusion Overloaded pressure could upregulate Hif-1 alpha and increase the ration of Rankl/Opg mRNA, which may contribute to osteoclastogenesis in periodontitis.关键词
人牙周膜细胞微球/压力/Hif-1 alpha/Rankl/OpgKey words
human periodontal ligament fibroblast pellets/ compressure/ Hif-1 alpha/ Rankl/Opg分类
生物科学引用本文复制引用
郭莉,徐静,郭宏刚..人牙周细胞压力作用下Hif-1 alpha及Rankl/Opg变化[J].中国美容医学,2012,21(15):1964-1966,3.
