中国普通外科杂志2012，Vol.21Issue(10)：1270-1274,5.
胸苷磷酸化酶在结直肠癌研究中的意义
Importance of thymidine phosphorylase in colorectal cancer investigation
摘要
Abstract
Investigations reveal thymidine phosphorylase has the effects of promoting tumor angiogenesis and inhibiting cell apoptosis, and is closely related to the prognosis and outcome of the cancer patients. Meanwhile, it is also the key converting enzyme for the prodrugs of 5-fluorouracil such as 5'-deoxy-5-fluorouridine. This paper reviews the advances in the investigation of thymidine phosphorylase; including its expression and function in colorectal cancer tissue, converting effect on 5'-deoxy-5-fluorouridine and therapeutic potential.关键词
结直肠肿瘤/胸苷磷酸化酶/新生血管化,病理性/5'-脱氧氟脲苷Key words
Colorectal Neoplasms/ Thymidine Phosphorylase/ Neovascularization, Pathologic/ 5'-deoxy-5-fiuorouridine分类
医药卫生引用本文复制引用
刘剑,高庆..胸苷磷酸化酶在结直肠癌研究中的意义[J].中国普通外科杂志,2012,21(10):1270-1274,5.基金项目
国家自然科学基金资助项目(81071883/H1612) （81071883/H1612）
广东省自然科学基金资助项目(04009573). （04009573）
