中国普通外科杂志2012，Vol.21Issue(11)：1362-1368,7.
高低剂量131I去除甲状腺癌术后残留功能性甲状腺组织的疗效与安全性评价
Efficacy and safety of two different doses of iodine-131 for post-thyroidectomy ablation of functioning remnants:a Meta-analysis
王可 1王洋 1罗军 1田野 1白超 1李新喜 1陆路 1代引海1
作者信息
- 1. 新疆医科大学第一附属医院血管甲状腺外科,新疆乌鲁木齐830054
- 折叠
摘要
Abstract
Objective: To assess the efficacy and safety of low- (l 100 mBq) and high-dose (3 700 mBq) iodine-131 (131l) for postoperative ablation of thyroid remnant in patients with differentiated thyroid cancer by using Meta-analysis. Methods: The literature of randomized clinical trials (RCT) concerning low- versus high-dose 131I in postoperative ablation of thyroid remnant in patients with differentiated thyroid cancer was searched using the national and international electronic databases. All relevant studies were screened according to inclusion and exclusion criteria, and then the included studies were evaluated, and finally, the extracted data were analyzed using RevMan 5.0 software provided by the Cochrane Collaboration. Results: Six RCTs were included, with a total of 1 141 patients (715 patients in low dose 131I group and 696 patients in high-dose 131I group). No statistical difference was noted in low- versus high-dose 13lI group with regard to the efficacy in ablation of residual thyroid tissue (OR=0.78, 95%CI=0.58-1.06, P=0.1l), incidence of dry eye (OR=0.77, 95%CI=0.53-1.12, P=0.18) and incidence of dry mouth (OR=0.69, 95%CJ=0.47-1.01, P=0.06). The incidences of both gastrointestinal adverse reactions and neck pain in low-dose 131I group were lower than that in high-dose 131I group (OR=0.32, 95%CI=0.18-0.55, P<0.001; OR=0.49, 95%CI=0.31-0.78, P=0.003). Conclusion: In differentiated thyroid cancer, the two doses of 131I have similar efficacy in postoperative ablation of thyroid remnant, but the low-dose regimen has less adverse effects.关键词
甲状腺肿瘤/放射性碘去除术/随机对照试验/Meta分析Key words
Thyroid Neoplasms/radiotherapy/ Radioiodine Ablation/ Randomized Controlled Trial/ Meta-Analysis分类
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王可,王洋,罗军,田野,白超,李新喜,陆路,代引海..高低剂量131I去除甲状腺癌术后残留功能性甲状腺组织的疗效与安全性评价[J].中国普通外科杂志,2012,21(11):1362-1368,7.
