中国普通外科杂志2012，Vol.21Issue(11)：1369-1372,4.
原发性甲状腺恶性淋巴瘤的诊断与治疗:附23例报告
Diagnosis and management of primary thyroid lymphoma:a report of 23 cases
摘要
Abstract
Objective: To investigate the diagnosis and treatment of primary thyroid malignant lymphoma (PTML). Methods: The clinical data of 23 patients with PTML admitted from January 2000 to December 2011 were retrospectively analyzed. Results: All patients had a history of a rapidly growing thyroid mass. Sixteen PTML cases had markedly high titers of anti-thyroid peroxidase antibody (TPOAb) and/or increased antithyroglobulin antibody (TGAb). Preoperative CT scan revealed that the mass was of lower density than the normal glandular and adjacent muscular tissues, and showed no evident enhancement on the contrast-enhanced scan. Of the entire group, 17 cases underwent radical resection and 6 cases had palliative operation. Eighteen patients received adjuvant chemotherapy (CHOP or COP regimen) and 5 patients underwent radiotherapy. The clinical stages were stage IE in 5 cases, HE in 17 cases and IIIES in one case, respectively. Fourteen cases were diffuse large B cell lymphoma (DLBCL) and 9 cases were mucosa-associated lymphoid tissue (MALT) lymphoma with regard to the pathological classification. During the follow-up up to January 2012,17 patients survived for periods from less than one year to more than 5 years. Conclusion: The rapidly enlarging thyroid mass in a background of Hashimoto's thyroiditis combined with the characteristic CT findings may tend to support the preoperative diagnosis of PTML. Surgical resection and postoperative radiotherapy or chemotherapy are the treatment modalities for this condition.关键词
甲状腺肿瘤/外科学/淋巴瘤/诊断,鉴别/综合疗法Key words
Thyroid Neoplasms/surg/ Lymphoma/ Diagnosis, Differential/ Combined Modality Therapy分类
医药卫生引用本文复制引用
张平,王志宏,贺亮,董文武,张浩..原发性甲状腺恶性淋巴瘤的诊断与治疗:附23例报告[J].中国普通外科杂志,2012,21(11):1369-1372,4.基金项目
辽宁省"百千万人才工程"资助项目(2010921070) （2010921070）
辽宁省教育厅创新团队资助项目(LT2010102). （LT2010102）
