中国普通外科杂志2012，Vol.21Issue(11)：1381-1384,4.
原发性甲状旁腺机能亢进患者术中监测甲状旁腺激素的临床意义
Clinical significance of intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism during parathyroidectemy
陈祥锦 1庄奕翔 1朱有志 1张惠灏 1孔令君 1吴坤琳 1王宗财1
作者信息
- 1. 福建医科大学附属第一医院甲状腺乳腺外科,福建福州350005
- 折叠
摘要
Abstract
Objective: To assess the clinical value of intraoperative parathyroid hormone (IOPTH) monitoring for patients with primary hyperparathyroidism (PHPT) during parathyroidectomy.Methods: The clinical data of 36 PHPT patients undergoing surgical treatment from January 1998 to January 2012 were retrospectively analyzed. Of the patients, 22 cases (before 2005) received IOPTH monitoring (IOPTH group) during surgery and 14 cases (after 2005) underwent parathyroidectomy without IOPTH monitoring (conventional group). The intraoperative conditions and therapeutic efficacies between the two groups were compared. Results: Compared with conventional group, in IOPTH group, the operative time was reduced [(72.95±24.34) min vs. (81.86±29.46) min, P=0.000], ratio of patients with short-term (within the first month after surgery) recovery of parathyroid function increased (90.9% vs. 57.1%, P=0.018), and incidence of permanent hypoparathyroidism decreased (4.5% vs. 28.6%, P=0.042). The sensitivity and accuracy of IOPTH monitoring for judgment of whether or not the hyperfunctioning lesions were completely resected was 100% and 95.5%, respectively. Conclusion: On the basis of preoperative localization, using IOPTH monitoring during parathyroidectomy is helpful to determine whether the hyperfunctioning glands are completely removed, and to avoid missing a synchronous lesion and unnecessary bilateral exploration. In addition, it reduces the operation time and is of precise efficacy.关键词
甲状旁腺机能亢进,原发性/外科学/甲状旁腺切除术/甲状旁腺素/血液Key words
Hyperparathyroidism, Primary/surg/ Parathyroidectomy/ Parathyroid Hormone/blood分类
医药卫生引用本文复制引用
陈祥锦,庄奕翔,朱有志,张惠灏,孔令君,吴坤琳,王宗财..原发性甲状旁腺机能亢进患者术中监测甲状旁腺激素的临床意义[J].中国普通外科杂志,2012,21(11):1381-1384,4.
