中国普通外科杂志2012，Vol.21Issue(11)：1410-1414,5.
Bmi-1及Mel-18在乳腺癌中的表达及其与临床病理特征的关系
Clinicopathological study of Bmi-1 and Mel-18 expression in breast cancer
胡花丽 1冯爱强 1张彦武 1雷冬梅 2王金礼1
作者信息
- 1. 郑州大学第三附属医院乳腺科,河南郑州450052
- 2. 郑州大学第三附属医院病理科,河南郑州450052
- 折叠
摘要
Abstract
Objective: To investigate the expression of Bmi-1 and Mel-18 in breast cancer tissue and their clinical significance. Methods: The gene and protein expression in malignant (40 cases), benign (20 cases) and normal (20 cases) breast tissues were determined by RT-PCR and immunohistochemical method, respectively. The Bmi-1 and Mel-18 expression status and their correlationship in breast cancer tissue, and the relations of their expressions with the clinicopathologic factors were analyzed. Results: Both mRNA and protein positive expression of Bmi-1 increased significantly and successively in normal, benign and malignant breast tissues (all P<0.05), while those of the Mel-18 showed a roughly opposite tendency (no significant difference between normal breast tissue and benign breast lesion). There was a significant negative correlation between Bmi-1 and Mel-18 expression at either mRNA or protein level in breast cancer tissue (r=-0.317, P=0.023 and r=-0.413, P=0.008). The mRNA and protein levels of both Bmi-1 and Mel-18 were significantly related to the lymph node metastasis and clinical stage (all P<0.05), but not associated with the age, menstrual status, tumor size and histologic classification of the patients (all P>0.05). Conclusion: The increased Bmi-1 expression along with decreased Mel-18 expression may probably be important biological markers for malignant transformation of breast tissue or invasion and metastasis of breast cancer.关键词
乳腺肿瘤/病理学/Bmi-1/Mel-18/肿瘤侵润Key words
Breast Neoplasms/ Bmi-1/ Mel-18/ Neoplasm Invasiveness分类
医药卫生引用本文复制引用
胡花丽,冯爱强,张彦武,雷冬梅,王金礼..Bmi-1及Mel-18在乳腺癌中的表达及其与临床病理特征的关系[J].中国普通外科杂志,2012,21(11):1410-1414,5.
