中国全科医学2012，Vol.15Issue(28)：3268-3270,3.DOI:10.3969/j.issn.1007-9572.2012.10.020
转化生长因子-β1与结缔组织生长因子在类风湿关节炎合并肺间质病变患者血清中的表达水平及临床意义
Expression Levels of Serum TGF-1 and CTGF in Patients with Rheumatoid Arthritis Complicated by Interstitial Lung Disease the Significance
闫慧明 1丁利芳 1刘媛 1庞春艳 1王永福1
作者信息
- 1. 014010,内蒙古自治区包头市,包头医学院风湿免疫研究所
- 折叠
摘要
Abstract
Objective To determine the expression levels of serum levels of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) in patients with rheumatoid arthritis complicated by interstitial lung disease (RA-ILD) so as to explore their clinical significance in ILD. Methods The serum levels of TGF-β1, CTGF in 100 RA patient (including 55 simple RA patients and 45 RA-ILD patients) and 50 healthy volunteers were detected by enzyme linked immu-nosorbent assay (ELISA) . Results The serum levels of TGF-β1, CTGF in patients in the RA-ILD group were statistically higher than those in the RA group and control group (P <0. 05). In the RA-ILD group the C-reactive protein was positively correlated with TGF-β1 (r = 0. 41, P = 0. 005) and CTGF (r = 0. 33 , P = 0. 029). Conclusion The serum levels of TGF-β1 and CTGF were related with development of RA-ILD, and they may take part in the pathogenesis of RA-ILD by increasing the levels of C-reactive protein. So the levels of TGF-β1 and CTGF may be one of the early markers to screen RA-ILD.关键词
转化生长因子-β1/结缔组织生长因子/类风湿关节炎/肺间质病变Key words
Transforming growth factor-β1/ Connective tissue growth factor/ Rheumatoid arthritis/ Interstitial lung disease分类
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闫慧明,丁利芳,刘媛,庞春艳,王永福..转化生长因子-β1与结缔组织生长因子在类风湿关节炎合并肺间质病变患者血清中的表达水平及临床意义[J].中国全科医学,2012,15(28):3268-3270,3.
