中国全科医学2012，Vol.15Issue(29)：3368-3370,3.DOI:10.3969/j.issn.1007-9572.2012.10.054
P16INK4a蛋白及人乳头瘤病毒检测对宫颈癌前病变的预测价值
Value of Immunocytochemical Staining of P16 INK4a Protein Combined with Human Papillomavirus Test for the Detection of Cervical Intraepithelial Neoplasia
摘要
Abstract
Objective To evaluate the value of immunocytochemical staining of P16 INK4a protein combined with human papillomavirus (HPV) test for detecting cervical intraepithelial neoplasia (CIN). Methods Totally 705 patients with pathologically confirmed CIN in our hospital from November 2008 to October 2011 were enrolled in this study. We made a retrospective study of the clinical and pathological data by immunocytochemical staining of P16 INK4a protein combined with HPV test. Results The sensitivity of the positive rate of P16 INK4a in high-grade CIN was significantly higher than that of HPV DNA test (X2 = 20. 642, P <0. 05). The positive rate of P16 INK4a protein staining was positively correlated with the pathologic degree of lesions (X2=38. 432, P <0. 05), while the positive rate of P16 INK4a test was positively correlated with the pathologic degree (r =0. 2580, P <0. 05) the positive rate of HPV DNA test was negatively correlated with the pathologic degree (r =-0.530, P <0. 05). Conclusion The immunocytochemical staining of pl6 INK4a protein has a higher sensitivity than HPV DNA test in detecting high grade CIN, and therefore it, when combined with HPV DNA test, has a high predictive value for CIN.关键词
宫颈上皮内瘤样病变/治疗/人类乳头病毒/P16 INK4a蛋白Key words
Cervical intraepithelial neoplasia/ Treatment/ Human papilloma virus (HPV DNA)/ P16 INK4a immunostaining protein分类
医药卫生引用本文复制引用
金艳,曹树军,杨道华,施华珍,钱金风..P16INK4a蛋白及人乳头瘤病毒检测对宫颈癌前病变的预测价值[J].中国全科医学,2012,15(29):3368-3370,3.基金项目
上海市松江区医学领先专业建设资助项目(05-Ⅰ-04) （05-Ⅰ-04）
上海市松江区科技攻关项目 （）
